Bromelain extract (Bromelain extract 1200GDU) in powder 80g.

Bromelain is a natural proteolytic enzyme complex derived from pineapple (Ananas comosus). It has a long history of medicinal use in Central and South America and is now one of the most studied natural enzymes in the world.
It is used both orally and topically, with applications ranging from inflammation and pain , to sinusitis , asthma , bronchitis , osteoarthritis , cardiovascular , and the removal of dead tissue in burns.

Bromelain is classified as a dietary supplement and has been designated as generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA).

What is bromelain and how does it work?

Bromelain is a mixture of protein-digesting enzymes extracted from the stem, fruit and juice of pineapple. Thanks to its action:

• reduces inflammation and swelling
• contributes to the breakdown of mucus (due to its protein components)
• helps reduce pain and muscle stiffness
• supports protein digestion

Consuming pineapple or pineapple juice is not sufficient for therapeutic effect, as the doses required are much higher.

What is the typical dosage and recommended way to use Bromelain?

Bromelain powder with a strength of 1200 GDU per gram is of high enzymatic activity and requires relatively small quantities

• together with meals supports the digestion and breakdown of proteins
  The dosage ranges from 250 to 500 mg. In this case, bromelain is taken with or immediately after a meal, especially when the meal contains meat, fish, eggs or cheese.
• on an empty stomach mainly targets inflammation, mucus and pain
  The recommended daily amount ranges from 500 to 1000 mg. This amount is taken in two doses of 250 to 500 mg, one in the morning and one in the late afternoon. It should be taken on an empty stomach, approximately 45 to 60 minutes before eating or at least two hours after, so that the enzyme can be absorbed and act systematically and not just in digestion.
• For more intensive and short-term use, such as in cases of severe inflammation or injury,
  The daily dose can reach 1200 to 1500 mg for a period of seven to fourteen days. Here too, the intake is done in divided doses and on an empty stomach.
• 500mg is equivalent to approximately ¼ teaspoon while 1000mg is equivalent to half a teaspoon.

It is best to use in consultation with a healthcare professional.

What are the health benefits of Bromelain?

Osteoarthritis
Clinical studies show that bromelain has anti-inflammatory and analgesic effects, helping to reduce:

• of pain
• soft tissue edema
• joint stiffness
• Particularly positive results have been observed in knee and shoulder arthritis, with doses up to 400 mg twice daily.

Bronchitis and productive cough:

Its use is based mainly on its mucolytic and anti-inflammatory effects (and less on direct cough suppression). Bromelain appears to:

• regulates excessive inflammatory response
• supports the defense without "blocking" the body
• reduces inflammatory mediators
• reduces swelling of the airways
• improves airflow

This is important in:
chronic bronchitis , upper respiratory infections , prolonged cough after a cold

Asthma and allergic airway diseases

Studies in animal models show that the anti-inflammatory properties of bromelain may be beneficial in:

• asthma
• allergic inflammation of the airways

Chronic sinusitis and rhinosinusitis

Clinical data shows that taking bromelain daily for up to 3 months can reduce:

• swelling
• nasal congestion
• sinus pressure

Digestive support

Bromelain is a proteolytic enzyme that helps break down proteins, facilitating digestion and reducing symptoms such as heaviness in the stomach, bloating and discomfort after meals. It is often used as a natural digestive enzyme, especially after heavy or protein-rich meals.

Colitis and inflammatory bowel diseases

Experimental studies show that pure bromelain:

• reduces inflammation
• contributes to the healing of mucosal ulcers

Cardiovascular diseases

Bromelain appears to:

• inhibits platelet aggregation
• reduces the risk of thrombosis
• supports cardiovascular health

It has been studied in diseases such as:
peripheral arterial disease, hypertension, heart attack, stroke

Cancer

Preclinical studies show that bromelain:

• may have a positive effect by inhibiting the growth of cancer cells
• may interfere with key biological pathways that support malignancy

This area remains a subject of active research.

Special precautions

In high doses, bromelain can cause:
Diarrhea, nausea, vomiting, increased menstrual bleeding

Important contraindications
Bromelain slows blood clotting time, so it should be avoided in people taking anticoagulant medications and discontinued before and after surgery.
Not recommended for people with pineapple allergies

Conclusion
Bromelain is a powerful, natural enzyme with multi-level action, which has been extensively studied in inflammation, pain, respiratory congestion, cardiovascular health and tissue healing.
Correct use and dosage are crucial for maximum effectiveness.

Indicative bibliography

• Properties and Therapeutic Application of Bromelain: A Review
• Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms
• Bromelain: a review of its mechanisms, pharmacological effects and potential applications
• Clinical uses of bromelain: a narrative review of the scientific literature